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Juillet 2018

Lundi
02/07/2018
11h00

Salle condorcet

« Deciphering the anatomy and function of an inter-hemispheric neural circuit in the zebrafish optic tectum »

 

Filippo DEL BENE (Inst. Curie, Paris)

Lundi
02/07/2018
11h00

Amphi Pasteur

 

“ On the fight between cytotoxic T lymphocytes and cancer cells at the lytic synapse”

 

 

Dr. Salvatore VALITUTTI ( Cancer Research Center of Toulouse)

contact : melanie.wencker@inserm.fr

Mardi
03/07/2018
09h00

Salle de conférence de l'IBCP

«  Meet the Qex!»

 

PROGRAMME
• 9h-9h30 : Café et visite du laboratoire de protéomique
• 9h30-9h50 : Présentation du nouveau spectromètre de masse
Orbitrap: performances et applications en protéomique :
Adeline Page, PSF
• 9h50-10h30 : Retours d’expérience :
Thomas Henry CIRI, Christian Lesterlin MMSB, Catherine Moali
LBTI, Jérôme Lemoine ISA.

Mardi
03/07/2018
11h30

Salle des thèses CRC

“ Dendritic cell migration : from microfluidics to in vivo imaging ”

 

 Ana-Maria LENNON-DUMENIL (Institut Curie – U932 INSERM , Paris – FRANCE)

Contact : marlene.dreux@ens-lyon.fr melanie.wencker@inserm.fr

Immature dendritic cells (DCs) patrol the interstitial space of peripheral tissues thanks to their remarkable antigen macropinocytic and phagocytic capacity. Encounter with danger-associated antigens triggers a developmental program referred to as “DC maturation”, which modifies many of their cell biological properties. This includes the up-regulation of the chemokine receptor CCR7, which allows mature DCs entering into lymphatic vessels and migrate to lymph nodes to activate T lymphocytes, as well as the down-regulation of macropinocytosis. In my talk, I will show how regulation of actin nucleation by Arp2/3 and Formins differentially regulates migration and macropinocytosis in immature and mature DCs (Vargas et al. Nat.Cell Biol. 2016) and discuss unpublished results highlighting that macropinocytosis (1) links nutrient sensing to DC migration and (2) impacts on the ability of these cells to move in environments displaying high hydraulic resistance.

 

 

 

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