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IVPC- Biology of Phleboviruses group

Presentation

 

Negative-strand RNA viruses include some of the most notorious pathogens. Among them, those with segmented genome, such as the members of the Bunyaviridae family, represent the largest and, probably, the most diverse group infecting animals, insects and plants. Notably, bunyaviruses are transmitted to vertebrates by rodents or arthropods, and represent more than half of the known Arthropod-Borne viruses (arboviruses).

Importantly, the bunyavirus genome contains three segments referred to as Seg-L, Seg-M and Seg-S and rapid evolution of these viruses occurs naturally through RNA segment reassortment, mostly involving the interchange of the Seg-M. The Bunyaviridae family includes the Rift Valley Fever Virus and Toscana virus (Phlebovirus genus) which represent significant threats for many human populations and livestock animals. Despite presenting a similar genomic organization, these arboviruses display distinct biological properties and their Seg-M encoded proteins may govern key aspects of cell-host-vector interactions. Hence, the propensity of bunyaviruses to drastically evolve by Seg-M genetic shift leads to key inter-related points to address, including: i) the association between the Seg-M genetic shift and the emergence of viruses with altered vector or host range, route of transmission, virus spread to target organs and tissue/cell tropisms, ii) the identification of the Seg-M molecular determinants and the functional mechanisms governing virus-cell-host-vector interplay, and iii) the possibility to foresee the consequences of Seg-M genetic shift on the biological properties and vector-host interactions of newly emerged segmented-viruses.

Thus, the aim of our team is to conduct in vitro and in vivo comprehensive approaches to assess the impact of the RVFV and TOSV proteins in differentially modulating virus-host-vector interplay and investigate their cellular functions. Finally, although several laboratories are very proactive in the development of RVFV vaccines, there are still no therapeutics or vaccines available against these two viruses. Therefore, another key aspect of our research program is to develop innovative antivirals and diagnostics tools for these two bunyaviruses.

 

 

Contact

 

  1. Responsable d'équipe : Frederick Arnaud
  2. Adresse : UMR 754 INRA-ENVL-UCBL-EPHE
    1. 50, Avenue Tony Garnier
    2. 69366 Lyon Cedex 07
    3. Téléphone :
    4. Fax :
  3. E-mail : frederick.arnaud@univ-lyon1.fr

 

 

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