September 2017
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Lundi 08/04/2019 11H00 Salle Condorcet Séminaire externe |
« How can hundredsof cell types be built froma singlegenome? Evolutionary mechanisms for proteome specialization » | |
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Manuel IRIMIA (CRG Barcelona) Host: Abderrahman Khila |
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Lundi 15/04/2019 11H00 Salle Condorcet |
« Closing in on the deadline - The molecular regulation of developmentally controlled programmed cell death in plants » | |
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Moritz NOWACK (VIB Ghent, Belgium) Host: Gwyneth Ingram
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Lundi 15/04/2019 10H00 Salle réunion IVPC-UMR754 Séminaire externe |
« titre à venir » | |
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Dr Valérie CHOUMET (Environment and Infectious Risks Laboratory - DEPARTMENT OF INFECTION & EPIDEMIOLOGY Institut Pasteur Paris)
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Mardi 16/04/2019 14H00 IBCP conf Séminaire externe |
« Biomaterials in Musculoskeletal Tissue Repair and Regeneration » | |
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David EGLIN (AO Research Institute of Davos) Invité par Frédéric Mallein-Gerin
In the last two decades, the AO Research Institute Davos (ARI) has become a multidisciplinary group focusing on a holistic approach of the repair of traumatic and degenerative injuries, notably combining specialist knowledge in Biomaterials and processing technologies (e.g. biofabrication). To illustrate the translational and exploratory Biomaterials research performed at the ARI, 1/ the development of a bioactive material patient-specific implant (PSI) made by stereolithography for craniomaxillofacial application, 2/ the design of hyaluronan hydrogel bioink for cartilage repair and 3/ innovative technologies for the fabrications of cellularised 3-dimensional constructs, will be reported. |
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11h00 Amphi Pasteur Séminaire externe |
« The NLRP3 Inflammasome in homeostasis and disease » | |
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Pr Guangxun MENG (Unit of Innate Immunity, Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences)
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Lundi 29/04/2019 11h00 IBCP conf Séminaire externe |
« Managing the Bacterial Chromosome » | |
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David SHERRATT (University of Oxford, UK) Invited by C. Lesterlin We use quantitative single-cell and single-molecule analysis to understand how the E. coli chromosome is organised and managed in living cells, in order that the chromosome can be a template for gene expression, DNA replication and repair, and chromosome segregation. We track the position and action of single protein complexes over time in cells and determine their stoichiometry in steady state and perturbed conditions. A major focus of our work is the E. coli SMC complex, MukBEF, which acts in chromosome organisation-segregation through the action of MukBEF complexes alone on DNA, and through their interactions with Topoisomerase IV and MatP-matS. The working hypothesis is that MukBEF complexes can transport themselves rapidly and directionally with respect to chromosomal DNA, extruding DNA loops as they do so. Consistent with this, we demonstrate that MukBEF forms ring-shaped axial filaments ~120 nm wide around the chromosome, from which ~25 kbp loops emerge. Our data reveal how MukBEF organizes the chromosome and suggest a common mechanism between prokaryotic and eukaryotic SMC action. |
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Mardi
Salle Condorcet Forum d'infectiologie
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“ What can we learn from ancient horizontal gene transfer in Mycobacterium tuberculosis? ” | |
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Olivier Neyrolles (Directeur de l’Institut de Pharmacologie et de Biologie Structurale (IPBS) CNRS - Université de Toulouse) Contact : thomas.henri@inserm.fr
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