April 2016
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Lundi
04 / 04 / 2016 11h00 |
"From differentiated cells to progenitors; a view from the Drosophila tracheal system"
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par Jordi CASANOVA (IRB Barcelona) Salle des Thèses Chantal Rabourdin-Combe |
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Vendredi
08 / 04 / 2016 11h00 |
"Distinct disorders one culprit : new insights into the links between the aging process, prion maladies and Alzheimer’s disease"
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par Ehud COHEN (Hebrew University, Jerusalem)
Salle des Thèses Chantal Rabourdin-Combe |
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Mercredi
13 / 04 / 2016 11h00 |
"Assemblage du système de sécrétion de Type VI"
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par Eric CASCALES (Laboratoire d’Ingénierie des Systèmes Macromoléculaires, CNRS Université Aix-Marseille - FRANCE) Contact: thomas.henry@inserm.fr Dr Eric Cascales, who works at the Laboratory of Macromolecular Systems Engineering (LISM) at the National Centre for Scientific Research (CNRS) in France. Dr Cascales will present his research on bacterial type VI secretion systems (T6SS). Eric is a leader in the field of bacterial secretion systems with a special emphasis on the Type VI secretion systems . The T6SS is an amazing molecular syringe allowing bacteria to fight and kill other bacteria and allowing certain bacterial pathogens to inject virulence factors into host cells Amphi Pasteur CERVI
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Jeudi
21 / 04 / 2016 11h00 |
"Computational flow cytometry : helping to make sense of high-dimensional immunology data"
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par Yvan SAEYS (VIB Inflammation Research Center, Gent - BELGIQUE) Contact: jacqueline.marvel@inserm.fr The group of prof Yvan SAEYS (Ghent University) studies the design and application of novel data mining and machine learning techniques. In the field of systems immunology, his group develops new computational approaches to unravel the regulatory landscape of immune cell differentiation and functioning. Amphi Pasteur CERVI
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Lundi
25 / 04 / 2016 11h00 |
"Conserved polarization control in free-living and obligate intracellular bacteria"
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par Patrick VIOLLIER (University of Geneva) invited by C. Grangeasse
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Lundi
25 / 04 / 2016 11h00 |
"Pathomechanism of severe adverse drug reaction: bench to bedside"
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par Riichiro ABE (Niigata University Graduate School of Medical and Dental Sciences, Japan) contact: jean-françois.nicolas@inserm.fr
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening mucocutaneous reactions characterized by extensive detachment of the skin. We recently showed that keratinocyte death in SJS/TEN can be triggered by the interaction of annexin A1 and formyl peptide receptor (FPR) 1 and may contribute to the pathogenesis of SJS/TEN. Annexin acts on FPR1, located on the surface of the skin cells, to cause necroptosis, a programed form of cell death.
I will also present current progress of anti-SJS/TEN drug development focusing annexin A1/FPR1 interaction.
References:
1. Saito N, Qiao H, Yanagi T, Shinkuma S, Nishimura K, Suto A, Fujita Y, Suzuki S, Nomura T, Nakamura H, Nagao K, Obuse C, Shimizu H, Abe R.
An annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions.
Sci Transl Med. 2014;6(245):245ra95.
2. Saito N, Yoshioka N, Abe R, Qiao H, Fujita Y, Hoshina D, Suto A, Kase S, Kitaichi N,
Ozaki M, Shimizu H.
Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients.
J Allergy Clin Immunol. 2013;131(2):434-41.
Amphi Pasteur CERVI
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