September 2017
Lundi 03/12/2018 Salle Condorcet Séminaire externe |
“ Modeling HIV and Zika pathogenesis in humanized mice ” | |
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Pr. Ramesh AKKINA ( Dept Microbiology, Immunology and pathology, Colorado State University – USA) contact : renaud.mahieux@ens-lyon.fr Humanized mouse (hu-mouse) models harboring a transplanted human immune system permit study of human pathogens in a setting mimicking the human host. Using this unique platform, our ongoing studies are focused on various aspects of viral pathogenesis, latency, therapies and human immune responses to HIV, Dengue and Zika. |
Mercredi Amphi Mérieux |
RHUMATOPEDIES | |
5eme journée nationale |
Contact : anne-laure.mathieu@inserm.fr
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Jeudi SDT CRC FINOVI KEYNOTE |
"The foreign within: Drosophila-Spiroplasma interaction as a model of insect endosymbiosis" | |
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Pr. Bruno LEMAITRE (Global Health Institute, EPFL) Host: François Leulier francois.leulier@ens-lyon.fr Virtually every species of insect harbors facultative bacterial endosymbionts that are transmitted from females to their offspring, often in the egg cytoplasm. These symbionts play crucial roles in the biology of their hosts. Many manipulate host reproduction in order to spread within host populations. Others increase the fitness of their hosts under certain conditions, for example by increasing tolerance to heat or by protecting their hosts against natural enemies. However, in spite of the growing interest in endosymbionts, very little is known about the molecular mechanisms underlying most endosymbiont-insect interactions. To fill this gap, we are dissecting the interaction between Drosophila and its native endosymbiont Spiroplasma poulsonii. Spiroplasma are members of the Mollicutes, a wall-less eubacterial group related to the Gram-positive lineage, which are very widespread and is likely to be present in over 5% of all insect species.
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Jeudi Amphi Pasteur Forum infectiologie |
“ Immune clocks : is there an ideal time to vaccinate and to fight infections ” | |
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Pr. Nicolas CERMAKIAN ( McGill University – Douglas Institute Research Centre Montréal - Canada) contact : yann.leverrier@inserm.fr Recent research has shown that various aspects of the immune system are regulated by circadian clocks, and thus, present 24 h rhythms. A short overview of the circadian control of immune functions will be presented, followed by our recent
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Lundi 10/12/2018 Mardi 11/12/2018 Matmut stadium |
Immunotherapies for Infectious Diseases Congress 2018 (I4ID2018) | |
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The 2nd Immunotherapies for Infectious Diseases Congress 2018 (I4ID2018), organized by MabDesign and BIOASTER, will bring together pharmaceutical industries, research labs, clinicians, service providers, technology developers and policy makers to exchange about the development of immunotherapy solutions for prevention and treatment of infectious diseases.
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Jeudi Amphi Pasteur Séminaire externe |
“ Les Héparanes Sulfate : des régulateurs « glycobiologiques ” | |
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Romain VIVES (IBS, Grenoble) contact : Olivier Reynard Dans la plupart des organismes pluricellulaires, la coordination des échanges d’information et des interactions entres cellules individuelles est orchestrée par une multitude de protéines extracellulaires solubles. Ces protéines messagères exercent leurs fonctions en interagissant avec des récepteurs spécifiques présents à la surface de cellules cibles, initiant ainsi des réponses biologiques définies. De nombreux mécanismes de régulation contrôlent leur activité, parmi lesquels interviennent une famille de polysaccharides complexes présents en abondance à la surface cellulaire et dans les matrices extracellulaires : les Héparanes sulfate (HS). En fixant ces effecteurs solubles, les HS vont contrôler et orienter leur diffusion, et donc l’accès à leurs récepteurs cellulaires, mais également affecter leur stabilité, structure et réactivité. Les HS jouent de ce fait un rôle central dans la plupart des grands processus physiologiques et pathologiques. Les propriétés d’interaction des HS sont liées à la présence au sein du polysaccharide de régions spécialisées (les domaines S), caractérisées par leur séquence saccharidique et leur profil de sulfatation, et contenant l’information structurale nécessaire à la reconnaissance de leurs ligands. L’expression et la structure des HS constituent donc un levier de régulation important pour la cellule, lui permettant d’adapter sa réponse à un vaste répertoire de stimuli externe.
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Vendredi Salle condorcet Séminaire externe |
« The p21‐mTert knock‐In mouse: Escape of senescence and deregulation of signaling and metabolic pathways. » | |
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Vincent GELI (CRCM, Marseille) Contact : F. Palladino
Of the stresses that trigger cellular senescence, unrelenting telomere shortening plays a particularly important role because this serves as a "biological clock" that regulates the lifespan. The "clock" starts ticking when telomerase is shut down before birth in most somatic tissues. A key regulator of cellular arrest in response to telomere shortening is the cyclin-dependent kinase inhibitor p21. p53-dependent upregulation of p21 is thought to be the primary event inducing replicative senescence. We asked whether aging can be delayed by abrogating telomere shortening in senescent cells by expressing telomerase "only when it is needed" and what would be the consequences of this conditional ectopic expression of telomerase. Indeed, previous studies revealed that overexpression of telomerase promotes cell proliferation and inflammation independently of its activity at telomeres. To this purpose, we have created a knock-in mouse model in which a cassette encoding mCherry-2A-mTert (telomerase) has been inserted after the first exon of p21 (p21-mTert mouse). Our results indicate that expression of telomerase driven by the p21Cdk1a promoter decreases the number of senescent cells in the lung parenchyma and prevents emphysema, either in old mice or in mice experiencing hypoxia. Collectively, our results indicate that p21-mTert mice are protected from lung dysfunction related to cellular senescence. Strikingly, we also observed unexpected phenotypes associated to this ectopic telomerase expression. Indeed, p21-mTert mice exhibit a gradual increase in body weight, exhibited white fat accumulation, liver dysfunction, steatosis, and hepatocarcinoma. Moreover, p21-mTert mice show clear defects in vascular patterning. The phenotypes exhibited by the p21-mTert mice make this mouse model a very attractive model to understand the canonical and the non canonical role of telomerase.
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Jeudi Amphi Pasteur Séminaire externe |
“ Amino acid sensing and immune Regulation ” | |
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Dr. Marion RUSSIER ( Max Planck Institute of Biochemistry Martinsried - Germany) contact : sylvain.baize@pasteur.fr The immune response consumes high amounts of energy and nutrients. Immune cells require external supplies of most amino acids, including non-essential ones. This necessity, called, amino acid auxotrophy, has evolved to become an
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