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September 2017


Salle condorcet

« From data to perception and return: Visualization in cellular and molecular biology »


Monica ZOPPE (Institute of Clinical Physiology – CNR, Italy)

Hôte : O. Gandrillon

The importance of visualization in science is testified by the efforts that many scientists employ in order to organize information (data, diagrams, plots etc.) in a visual way. For human beings it is perfectly natural to extract meanings from visual clues, and we do so often unconsciously.
In the fields of cellular and molecular biology, the use of 3D techniques to convey information is also intrinsically linked to the nature of the data: structural biology and the many new microscopy technologies all provide spatial information which is three dimensional in nature. However, only a subset of data can be extracted in 3D, whereas we could exploit the 3D environment in a much larger set of situations.
An important aspect, sometimes overlooked, is that visualization starts in our mind: we will explore the techniques and the promises of visualization with some direct experience, and show how this effort contributes to increasing our scientific understanding of cellular phenomena.


ENS Amphi A


«Genome-wide enhancer-gene associationmaps in human and zebrafish, and application to human diseases»





Contact : YadGhavi-Heim


Salle de conférence de l'IBCP

Séminaire externe

“ Single-cell imaging and characterization of Escherichia coli persister cells to ofloxacin ”

Laurence Van MELDEREN (Université libre de Bruxelles, Belgique)                           

  invited by C. Lesterlin

Bacterial persistence to antibiotics refers to the capacity of small subpopulations within clonal populations to tolerate antibiotics. Persisters are thought to originate from dormant cells presenting reduced metabolic activity, in which antibiotic targets are less active than in dividing cells and therefore less corruptible by antibiotics. Here we report that persisters generated in exponentially growing cultures treated with ofloxacin are originating from metabolically active cells: these cells are dividing prior the addition of ofloxacin and do endure DNA damages during the treatment, similarly to their non-persister siblings. We observed that growth rate and SOS induction vary among persisters, as in the bulk of population. Therefore, none of these parameters constitute predictive markers for persistence. Our findings highlight the heterogeneity of persister cells and therefore the need to analyze these low frequency phenotypic variants on a case-by-case basis at the single-cell level.


Aquarium de Lyon

Colloque Santé@LabEx


Suite au succès de la 1ère édition organisée le 16 décembre 2016, les LabEx Santé de l'Université de Lyon réitèrent l'expérience et vous invitent à participer à la 2ème édition de cette journée collaborative. Cette journée de rencontres entre les membres des LabEx en Santé Cortex, DevWeCan, Ecofect et Primes, ainsi que les autres LabEx lyonnais souhaitant participer, a pour objectif la mise en place de programmes de recherche interdisciplinaire. Le programme se concentrera sur deux aspects : la gestion des Big Data et le retour d'expérience de collaborations entre chercheurs et cliniciens.
Dr. Chloé-Agathe Azencott (Centre de Bio-informatique, Mines ParisTech, Institut Curie, Inserm) et Dr. Alain Viari (Directeur scientifique de la Plateforme de Bioinformatique Gilles Thomas, CLB, Lyon) présenteront des conférences plénières. Inscription :





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