September 2017
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Lundi Séminaire externe Salle Condorcet |
« Arabidopsis pavement cells: An integrated system for piecing together the puzzles of cell morphogenesis in Plants » |
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Zhenbiao YANG (Univ. of California Riverside, USA) Host: Yvon Jaillais |
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Mercredi Séminaire externe Amphi Pasteur |
“ Innate immune competency of two New World bat species ” | |
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Dr Anne LAVERGNE (Laboratoire des Intéractions Virus-Hôtes, Institut Pasteur de la Guyane - Cayenne) contact : branka.horvat@inserm.fr
Bats are associated with several deadly emerging viruses such as rabies virus, SRAS, Ebola or Nipah. Although these viruses are often fatal in humans, they do not seem to cause any symptoms in the bats. One of the hypotheses to explain the "tolerance" of bats to infection is that they possess a particular innate immune system that allows them to quickly control viral infection. In order to characterize the innate immune competency in New World bats, several genes related to the interferon system such as Toll-like receptors, RIG-I-like receptors Interferon 1 and as well as some IFN-stimulated genes (OAS-1, PKR, ADAR) were described in Desmodus rotundus and Carollia. perspicillata. In parallel, two immortalized cell lines have been established from the same two species. This allowed us to evaluate the efficacy of the bat pathogen recognition receptors and to follow induction of the IFN pathway in the bat cell lines upon stimulation using Poly(I:C) that confirm a robust and functional IFN pathway. |
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Jeudi Forum d'infectiologie Salle SdT CRC |
“ Virus defense at the brain border ” | |
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Pr. Ulrich KALINKE Centre for Experimental and Clinical Infection Research Hanover - Germany) contact : marlene.dreux@ens-lyon.fr Many viruses exploit the odorant system and enter the CNS via the olfactory bulb (OB). Upon intranasal vesicular stomatitis virus instillation, we show an accumulation of activated microglia and monocytes in the OB. Depletion of microglia during encephalitis results in enhanced virus spread and increased lethality. Activation, proliferation, and accumulation of microglia are regulated by type I IFN receptor signaling of neurons and astrocytes, but not of microglia. Morphological analysis of myeloid cells shows that type I IFN receptor signaling of neurons has a stronger impact on the activation of myeloid cells than of astrocytes. Thus, in the infected CNS, the cross talk among neurons, astrocytes, and microglia is critical for full microglia activation and protection from lethal encephalitis. |
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Lundi Séminaire externe Salle Condorcet |
« Trends in publishing at Journal of Cell Science, a community journal » | |
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Manuel BREUER (Journal of Cell Science Editor) Host: Olivier Hamant
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Séminaire externe Amphi Pasteur
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“ Local players in immunity: differentiation and functions of tissue-resident lymphocytes ” | |
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Dr Georg GASTEIGER (Julius-Maximiliams University of Würzburg ; Würzburg institute of systems immunology, RFA) contact : thierry.walzer@inserm.fr
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