September 2017
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Vendredi Salle de réunion IVPC |
" The epigenetic code of influenza A virus nucleoprotein defines replication steps and place in infected cells " | |
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Dr. Ke XU (Institut Pasteur Shanghai) Contact : Carine Maisse-Paradisi |
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Vendredi Salle des thèses Chantal Rabourdin-Combe
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« Dissecting the sources of phenotypic variation among genetically identical individuals growing in the same environment » | |
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Mirko FRANCESCONI (Centre de Regulacio Genomica, Barcelona) Genetically identical individuals growing in the same environment often show substantial phenotypic variation. The reasons for this phenotypic variation are usually unknown. We found that isogenic C. elegans growing in the same environment differ in developmental speed, including the relative developmental rate of the soma and the germline (soma-germline heterochrony), fecundity and many other fitness important traits such as size and resistance to early starvation. We found maternal age to be the major determinant of this phenotypic variation in with progeny of young mothers being surprisingly impaired in size, developmental speed, starvation resistance and fecundity, and they also show different soma-germline heterochrony. Changes in maternal provisioning of yolk to the embryo, which increases with age, explain many of these phenotypic differences but do not explain differences in soma-germline heterochrony and fecundity. We now have obtained preliminary results showing that parental exposure to pheromone also induces phenotypic differences in the offspring, including soma-germline heterochrony and fecundity, which are not explained by a change in yolk provisioning. |
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Mardi Amphi Pasteur |
“ Pleiotropic treatment of cancer: RANK inhibitors targeting cancer stem cells and immunity ” | |
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Dr Eva GONZALEZ SUAREZ (Cancer Epigenetics and Biology Program IDIBELL, Hospital Duran i Reynals) Contact : thierry.walzer@inserm.fr
Thousands of cancer patients worldwide are taking RANKL inhibitors for the management of bone metastasis, based on the key role of RANKL and its receptor, RANK, in osteoclasts. I will comment on the role of RANK signaling in mammary gland development and cancer using mouse models and human clinical samples and the possibility of using RANK pathway inhibitors for the treatment of breast cancer. Finally I will discuss the multiple divergent effects in immunity and inflammation that RANK pathway has and how they may influence tumor immunity.
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Jeudi Salle de réunion IVPC |
" Infections arbovirales : transmission virale, adaptation à l’hôte, et propagation " | |
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Pierre-Yves LOZACH (Department of Infectious Diseases, University Hospital Heidelberg) Contact : Carine Maisse-Paradisi
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Salle des thèses Chantal Rabourdin-Combe
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« RNA modifications define a functional oocyte transcriptome » | |
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Marcos MORGAN (University of Edinburgh)
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Lundi Salle des thèses Chantal Rabourdin-Combe |
« Impact of gut microbiota on sex-dimorphic liver rhythmic gene expression and metabolism » | |
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Frédéric GACHON (EPFL, Lausanne) | |
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Mardi 19/06/2018 Amphi Pasteur |
“Drug allergy is no allergy” | |
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Pr. Werner J PICHLER (ADR-AC GmbH – CH 3008 Bern) Contact : jean-francois.nicolas@chu-lyon.fr
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