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Mai 2021

Lundi

03/05/2021
15h

Visio

Séminaire Externe

« The Non-Mendelian Genetics of Pollen Function »

John FOWLER (Oregon State University, USA)
Host: Nath Jacquier

Vendredi 07/05/2021
11h

Visio

Séminaire Externe

 

« When viral RNA met the host cell: a story of protein-RNA interactions »

 

Alfredo CASTELLÒ PALOMARES (University of Oxford - Department of Biochemistry)                    
Contact : E. Ricci

Lundi 10/05/2021
15H

Visio

Séminaire Externe

" Eco-evo-devo: molecular mechanisms and evolutionary causes of phenotypic variation and divergence "

Patricia BELDADE (Lisbon University)

Mardi 11/05/2021
11H00

Visio

Séminaire Externe

 « The dendritic cell population cDC1 produce IFN-λ in human primary tumors and are associated with a good prognosis.»

Dr Jenny VALLADEAU (CRCL, Lyon – France)
Hôte: Henri Gruffat
 
Immunotherapies and monoclonal antibodies targeting immune checkpoints have revolutionized cancer therapy. However, only a fraction of patients responds to these treatments. It is therefore crucial to develop new therapeutic strategies to induce or reactivate an efficient anti-tumor immune response. cDC1 dendritic cells are currently under scrutiny, given their extensively-described implication in antitumor immunity and response to immunotherapies in mice. One of their major features is their capacity to produce type III interferon (IFN-III). Indeed, IFN-III share signalling pathways with type I IFN, and experiments conducted in mice have demonstrated an important function for IFN-I in antitumor immune responses.
We have recently highlighted a critical function for type III IFN in shaping the composition of the tumor microenvironment and explaining the strongest positive impact of cDC1 on clinical outcome in many human cancers compared to other DCs subset. By analyzing a large cohort of fresh breast and ovarian primary tumors (n = 107) and transcriptomic public data sets, we have demonstrated that type III IFN represents the predominant IFN in tumors which is specifically produced by cDC1. We further observed that type III IFN or its receptor is associated with a favorable patient outcome in human breast tumors, and more importantly that IFN-III or cDC1 activation through TLR3 triggering directly drives the expression of IL-12p70 and chemokines, which in turn recruit cytotoxic effector cells.
We are now developing multi-IF staining combining 7 markers on FFPE tumor sections permitting a comprehensive analyse of the immune contexture in situ and we are conducting scRNAseq on human tumor infiltrates to identify new immunotherapeutic targets and to better understand the specific functions of each DC subsets.
Lundi 17/05/2021
11H00

Visio

Séminaire externe
 

« Control of reproductive development in moss : The interplay between auxin synthesis and sensing »
Mattias THELANDER (Swedish University of Agricultural Sciences, Sweden)
Host: Yoan Coudert

Mardi 18/05/2021

11H00

Visio

Séminaire externe

 « Zooming in on replication cycle of respiratory viruses by in situ cryo-electron tomography »

Dr Petr CHLANDA (Heidelberg university)
Hôte: Marlène Dreux
 
We have established an in situ cryo-correlative light and electron tomography workflow to study cellular organelles are their interactions with viruses during infection in unperturbed conditions and at a molecular resolution. This method allowed us to describe the architecture of lamellar bodies present in type II pneumocytes and to capture influenza A virus entry intermediates. In addition, our data revealed a viral RNA network inside double-membrane vesicles and assembly steps of SARS-CoV-2.

voir site web: http://www.bioquant.uni-heidelberg.de/members/petr-chlanda.html

Lundi 31/05/2021

15h

Visio

Séminaire externe

" Mechanisms of epigenome maintenance during genome replication "

Nataliya PETRYK (Université Paris Diderot)

Lundi 31/05/2021

15h

Visio

Séminaire externe

« Cyanobacteria symbiosis and carbon-concentrating mechanism in hornworts »
Fay-Wei LI (Cornell University, USA)
Host: Yoan Coudert
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