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Mars 2020

Lundi

09/03/2020
11h

Salle des Thèses CRC

Séminaire Externe

«  Sub-membrane specificity in immune signalling regulates cell to cell connectivity”

Christine FAULKNER (JIC Norwich, UK)
Host: M.C. Caillaud

Mercedi au vendredi 11-13/03/2020
Days

Amphi Mérieux

Meeting of the SFTCG

« The Annual meeting of the SFTCG »

https://www.sftcg.fr/Congr%C3%A8s/Lyon-2020.aspx

Vendredi 13/03/2020
11h00

Salle des Thèses CRC

Séminaire Externe

« Mechanisms of centriole assembly »

Pierre GÖNCZY (EPFL Lausanne, Suisse)
Hosted by Marie Delattre

Lundi 16/03/2020

11H00

Salle des Thèses CRC

Séminaire Externe

Probing neural tissue organization and development with somatic transgenesis and 3D color imaging approaches

 Jean LIVET (Institut de la Vision, Paris)
Hosted by Jon Enriquez

Lundi 23/03/2020

11H00

Salle IBCP Conf

Séminaire externe
 

« Transcriptomics and post-transcriptional regulation in Acinetobacter baumannii »

Carsten KROGER  (Trinity College, Dublin, Ireland)
Invited by S. Salcedo

Mardi 24/03/2020

11H00

Amphi Pasteur

Séminaire externe

“ Invasive meningococcal disease : From basic research to clinical applications ”

Sandrine BOURDOULOUS (Institut Cochin – Paris)
Hosted by Patricia Doublet
 
Neisseria meningitidis (meningococcus) is a cause of meningitis and of rapidly progressing fatal septic shock. A crucial step in the pathogenesis of invasive meningococcal diseases is the adhesion of bloodborne meningococci to both peripheral and brain endothelia, leading to major vascular dysfunctions.
Our team has developed interdisciplinary approaches to elucidate the intricate network of interactions and molecular strategies selected by this bacterial pathogen to colonize human peripheral and brain vasculature and get access to the brain. We have demonstrated that the capacity of N. meningitidis to bind to peripheral and brain endothelial cells relies on the interaction between their type IV pili (Tfp) and a complex formed by the endothelial cell receptor CD147 and the b2-adrenergic receptor. More recently, we have demonstrated that meningococcal Tfp recognize specific glycan determinants exposed on these host cell receptors. Using a humanized mouse model of infection, we have revealed that Tfp-mediated interaction with vascular wall provides a niche for bacterial replication, triggering purpuric lesions, sustained bacteraemia and mice lethality. Finally, we have identified compounds, previously used in human medicine, that induce the disassembly of type IV within minutes. In the humanized mice model, these compounds reduce meningococcal colonization of the human vessels, reduce vascular dysfunctions, intravascular coagulation and inflammation, and they improve mouse survival. Targeting Tfp thus appears as particularly promising strategy to reduce virulence and combat infection diseases.

Vendredi 27/03/2020

11h

Salle des Thèses CRC

Séminaire externe

" titre à venir "

Sandra DUHARCOURT (Institut Jacques Monod, Paris)
Hosted by Francesca Palladino

Lundi 30/03/2020 11H00

Salle des Thèses CRC

Séminaire externe

 

«  Cell size determination and differential growth control in plants «

Jürgen KLEINE-VEHN
(live from BOKU Vienna, Austria)
Host: O. Hamant A low carbon experience by O. Hamant™

 

 

 

 
   
 
 
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