Mars 2023
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Vendredi 03/03/2023 Salle SDT CRC Séminaire Externe |
« How embryos shape themselves: mechanisms of epithelial morphogenesis in an in vivo model » | |
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Bénédicte SANSON (Dept. of Physiology, Development and Neuroscience, University of Cambridge)
Host : M Grammont
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Lundi 06/03/2023 Salle Condorcet Séminaire Externe |
« Shaping root architecture » | |
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Viola WILLEMSEN (University of Wageningen)
Host : Yoan Coudert
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Vendredi 10/03/2023 et 10h45 Amphi Pasteur Séminaire Externe |
« Unravelling the Host Cell Response to Arenavirus Infection » and “ Studying virus-host cell interactions and their role in ebolavirus biology using reverse genetics-based life cycle modelling systems “ |
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Dr. Allison GROSETH (Head, Laboratory for Arenavirus BiologyFriedrich-Loeffler-Institut, Institute of Molecular Virology and Cell Biology – Greifswald – Allemagne)
Hôte: Olivier Reynard
The host cell response to virus infection plays a critical role in determining the outcome of infection, in particular through its dual roles in antiviral control and immunopathology. We have been seeking to understand the regulation of various aspects of the host response to arenavirus infection at a molecular level, including apoptosis, the innate immune response, and inflammatory responses. These studies suggest not only complex, and in some cases overlapping, mechanisms of regulation, but also interplay between these processes that shed light on the virus-host interface.
Dr. Thomas HOENEN (Head, Laboratory for Integrative Cell and Infection Biology Head, BSL4 LaboratoryFriedrich-Loeffler-Institut, Institute of Molecular Virology and Cell Biology - Greifswald - Allemagne)
Hôte: Olivier Reynard Host cell factors are essential for the life cycle of viruses, yet for many viruses little is known about details of their virus-host cell interactions. For ebolaviruses and other highly pathogenic viruses the study of virus-host cell interactions is further complicated by the fact that work with infectious viruses has to take place under biosafety level 4 conditions. Reverse genetics-based life cycle modelling systems address this issue by facilitating studies of virus-host cell interactions at lower biosafety levels. Using these systems we have identified and characterised on a mechanistic level host factors such as CAD and NXF1 and their role in the life cycle of ebolaviruses and other highly pathogenic viruses. These studies define new molecular targets for antiviral approaches with a potential for broad spectrum efficacy against multiple viruses.
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Lundi 13/03/2023 Amphi Pasteur Séminaire Externe |
« Advanced virtual screen and AI-driven antiviral drug discovery » | |
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Hovakim ZAKARYAN (Laboratory of Antiviral Drug Discovery » au « Institute of Molecular Biology » à Erevan (Arménie)
Hôte: Pierre-Olivier Vidalain
In the last decade, computational drug discovery approaches, including machine learning-based algorithms, have been widely used in the drug discovery process. We have developed two different computational methods allowing us to effectively perform virtual screening and design of new chemical structures directly in the binding pockets of molecular targets. I will present the current results as well as discuss future perspectives of using our methods in the discovery of new chemical scaffolds with high therapeutic activities.
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Lundi 13/03/2023 Salle SDT CRC Séminaire Externe |
« Unravelling the molecular basis of the natural apomixis » | |
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Lucia COLOMBO (University of Milan)
Host : Gwyneth Ingram
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Jeudi 16/03/2023 Amphi Pasteur Inscription gratuite mais obligatoire https://forms.gle/DF722zqyPCpqbdFA9
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Symposium de la spécialité Immunologie du CIRI sur l’Immunité humorale en l’honneur du départ à la retraite de Thierry Defrance | |
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« Regulatory plasma cells: characterization and therapeutic utilization »
Simon FILLATREAU (Institut Necker Enfants Malades, Paris)
« Plasma cells rock! »
Marion ESPÉLI (Institut de recherche Saint Louis, Paris)
« Don't let me B misunderstood »
Toufic RENNO (Centre de Recherche en Cancérologie de Lyon)
“ Going back home “
Thierry Defrance (Centre International de Recherche en Infectiologie, Lyon)
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Vendredi 17/03/2023 11H00 Amphi Pasteur
Séminaire Externe
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« TBA »
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« Enveloped Virus Entry Mechanisms: Past, Present and Future »
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Anne MOSCONA (Professor of Pediatrics, Physiology & Cellular Biophysics and Microbiology & Immunology, Columbia University)
Hôte: Branka Horvat
Sean WHELAN (Washington University in St. Louis)
Hôte: Louis-Marie Bloyet
Enveloped virus entry into cells requires fusion of viral and cellular membranes. This energetically unfavorable process is catalyzed by envelope proteins that function in conjunction with cellular factors to bring the viral and cellular membranes together. Using chimeric vesicular stomatitis viruses in which the native envelope protein is replaced with those of heterologous viruses we have probed how diverse enveloped viruses invade cells. Capitalizing on the cytolytic nature of vesicular stomatitis virus in cells in culture coupled with the ease of conducting genome-wide loss of function screens, we have identified host factors required for viral invasion of cells. In this presentation I will use examples of extinct, extant and emerging enveloped viruses to illustrate shared and unique mechanisms of enveloped virus entry.
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Lundi 20/03/2023 Amphi G2 de l'UCBL Nombre de participants est limité, inscription gratuite : https://evento.renater.fr/survey/mini-symposium-mmsb-march-20th-2023-j3312ymh
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Mini-meeting Molecular Microbiology and Structural Biochemistry (Organized by C. Grangeasse) | |
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“ TBA ”
Tom BERNHARDT (Harvard University, Boston, USA)
Mariana PINHO (ITQB, Lisbon, Portugal)
Rut CARBALLIDO-LOPEZ (MICALIS, Jouy-en-Josas, France)
Martin THANBICHLER (Max Planck institute, Marburg, Germany)
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Mardi 22/03/2023 Amphi Pasteur Séminaire Externe |
« Virus-host RNA-protein and protein-protein interactions and innate immunity » | |
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Anastassia KOMAROVA (Institut Pasteur - Laboratoire Interactomique, ARN et immunité
Hôte: Mathieu Mateo
Pattern recognition receptors (PRRs) protect against host invasion by detecting the specific molecular patterns of pathogens and initiating an immune response. The RIG-I-like receptors (RLRs) detect viral RNA mostly in the cytosol and trigger an intracellular signaling cascade that leads to the production of pro-inflammatory cytokines, including type-I interferon (IFN). We developed and validated novel ribonucleoproteomic approaches that consists of affinity purification of tagged RLRs from infected cells followed by next-generation sequencing (NGS) of associated RNA molecules and mass-spectrometry analysis of RLR-specific protein partners. Our recent results obtained using these approaches will be presented.
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Mardi 24/03/2023 Salle SDT CRC Séminaire Externe |
« TBA » | |||
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Nathalie BEAUJEAN (Stem cell and Brain Research Institute (SBRI), Bron)
Host :B. Loppin
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Lundi 27/03/2023 Salle SDT CRC Séminaire Externe |
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« Molecular mechanims of seed initiation in angiosperms »
Duarte D. FIGUEIREDO (Max Planck Institute for Molecular Plant Physiology, Golm)
Host : Benoit Landrein
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