« Alternative splicing : widespread fine-tuning regulatory process or costly errors ? »

par Laurent DURET Laboratoire de Biométrie et Biologie Evolutive, CRNS UCBL - FRANCE,

salle des Thèses Chantal Rabourdin-Combe, ENS de Lyon.

Host:  O GANDRILLON

« Catalytic impairment of succinate dehydrogenase sustains respiration but is unfavorable for proliferation »

par Dr. Doriane LORENDEAU Vesalius Research Center, Leuven, Belgium

IBCP Conference Room level -1

invited by Hélène Cortay.

Succinate dehydrogenase, or complex II, is important for  coupling between  Krebs cycle and respiratory chain. Mutations of this enzyme trigger neurodegenerative diseases (Leigh syndrome, ataxia) and rare cancers (paragangliomas, pheochromocytomas). This enzyme plays an adversarial role in terms of cell proliferation. Inhibition of its catalytic activity is investigated on metabolism and cell proliferation  by combining the tools of molecular biology and metabolomics/fluxomic studies.

« Proteogenemics : embracing the real complexity of proteomes »

par Jean ARMENGAUD CEA-Marcoule, DSV-Li2D

IBCP Conference Room level -1

invited by Catherine MOALI.

Proteogenomics is the alliance of genomics, transcriptomics, proteomics and bioinformatics for obtaining an improved annotation of genomes. Today, it is possible to document in a few weeks any biological species with high-throughput omics approaches and interpret the data focusing our attention on the key molecular players.  The application of proteogenomics approaches on non-model organisms such as new pathogens, exotic microorganisms, fungi, parasites, plants, invertebrates or vertebrates, allows understanding the specific traits of each organism. Its application to the catalogue of novel proteoforms formed during tumorigenesis (onco-proteogenomics) is of great interest. Mass spectrometers of the latest generation are recording such massive data on proteins that our vision of proteomics changed drastically. Some examples will be given to illustrate the proteogenomics approaches, their applications and perspectives.

Présentation du scanner de lames Axiscan ZI

"Automatisation de l'analyse du connectome chez le macaque par l'acquisition d'images haute définition en fluorescence" présenté par Camille Lamy chercheur au Stem Cell and brain research Institute (U846)

"Comparaison d'une histologie conventionnelle et d'une histologie virtuelle au moyen d'un scanner de lame" par D. Rousseau (CRETIS - Lyon I), T. Widiez (ENS de Lyon), S. Di Tommaso (CREATIS - LyonI) et P. Rogowsky (ENS de Lyon).

Amphi I, ENS de Lyon.

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« Systemic DNA damage responses in development and aging »

par Björn SCHUMACHER CECAD Research Center, University of Cologne,

salle des Thèses Chantal Rabourdin-Combe, ENS de Lyon.

« Diet controls the viable temperature range of Drosophila »

par Suzanne EATON - Max Planck Institute, Dresden

salle des Thèses Chantal Rabourdin-Combe, ENS de Lyon.

Hôte : M STRIGINI - IGFL

« Control of epithelial stresses and cell dynamics in Drosophila wing developement »

par Suzanne EATON - Max Planck Institute, Dresden

salle des Thèses Chantal Rabourdin-Combe, ENS de Lyon.

Hôte : M STRIGINI - IGFL

"Lymphocyte dynamics during pathogen defense"

par Wolfgang KASTENMÜLLER  Institute of Experimental Immunology (IEI) University of Bonn, Germany

Contact: Jacqueline MARVEL

" Legionella : de l'environnement à l'homme »

4ème édition du congrès scientifique SympoLegio, organisé par Le Centre National de Référence des Légionelles et l'équipe « Pathogénie des Légionelles » Ce colloque national  a lieu tous les deux ans à Lyon et rassemble plus de 200 personnes de toute la France.
La transdisciplinarité reste l'objectif du programme avec des intervenants et des participants issus de la santé publique, de la microbiologie clinique et environnementale et des sciences plus fondamentales. Différentes thématiques seront abordées et couvriront notamment les données épidémiologiques de la légionellose, les investigation de cas, les approches de Whole Genome Sequencing pour le typage des légionelles et pour une meilleure compréhension de la maladie, la résistance aux antibiotiques des légionelles et les relations hôtes pathogènes.

Pour en savoir plus et s'inscrire : page web

LyonSysBio is the yearly international conference organized by BioSyL , the Systems Biology Alliance of Lyon.
Its goal is to promote exchanges between scientists from different fields (biology, mathematics, computer sciences, physics, social sciences…) interested in the analysis of the wealth of data generated by modern biology, as well as the construction of the necessary modeling tools to gain system level thoughtful insights.
In 2015, the conference will be held from the 18th to the 20th of November in Lyon. It will be dedicated to discussions around the 4 following themes: systems immunology, cell differentiation, a systems view on genotype-phenotype relationship and microbiological systems biology. Keynote lectures will be delivered by the following speakers:

• Gregoire Altan-Bonnet (MSK cancer center, New-York)
• Becca Asquith (Imperial College, London)
• Chris Bakal (Institute of cancer research, London)
• Sckjoon Jun (University of California, San Diego)
• James Locke (University of Cambridge)
• John Marioni (European Bioinformatics Institute, Cambridge)
• Carsten Peterson (Computational Biology & Biological Physics, Lund University, Sweden)
• Andreas Wagner (IEU, University of Zurich)

Pour en savoir plus et s'inscrire : page web

« Probabilistic inferences in neural circuits : from insects to humans (to plants ?) »

par Alexandre POUGET University of Geneva Medical Center Department of Basic Neuroscience, Geneva, Switzerland & Department of Brain and cognitive Sciences, University of rochester, NY, USA

salle des Thèses Chantal Rabourdin-Combe, ENS de Lyon.

Hôte : Brian B. RUDKIN

« The HBc protein as antiviral target" »

par David DURANTEL  CRCL Lyon

IBCP Conference Room level -1

Invited by Anja Böckmann.