November 2016
Lundi
07 / 11 / 2016 11h00 |
"Bacterial conjugation: from molecular dissection to synthetic biology"
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Fernado de la CRUZ (Instituto de Biomedicina y biotecnologia de Canatbria (IBBTEC), Spain) Invited by the PhD students
IBCP Confernce Room level -1 |
Lundi
14 / 11 / 2016 11h00 |
"Evolution in Darwin’s Dreamponds: the adaptive radiation of cichlid fishes in East Africa”
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Walter SALZBURGER (Univ. Basel)
Salle des Thèses Chantal Rabourdin-Combe |
Mardi
15 / 11 / 2016 11h00 |
"Interfering with mRNA translation as a viralmechanism to evade the immune system and promote cell proliferation"
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Robin FAHRAEUS (Université Paris Diderot, Hopital Saint Louis, Paris - FRANCE) Contact: henri.gruffat@inserm.fr All Epstein-Barr virus (EBV)-infected cells express the nuclear antigen 1 (EBNA1) but despite the presence of CD8 T cells against EBNA1 epitopes in all virus-carrying individuals, the immune system fails to detect and destroy EBV-expressing cells. In order to achieve this immune evasion, the virus has evolved a mechanism whereby the EBNA1 inhibits its own synthesis in cis in order to suppress the production of antigenic peptides for the major histocompatibility (MHC) class I pathway. Studies on EBNA1-mediated interference with the mRNA translation machinery have revealed novel insights into the source and production of antigenic peptides for the MHC class I pathway. Drug screenings suggest that the unique mechanism whereby EBNA1 controls its own expression is a potential therapeutic target. The other aspect of EBNA1-mediated disruption of ribosomal activity relates to cell proliferation. Burkitt’s lymphomas are characterized by c-myc and EBNA1overexpression but the putative “relationship” between EBNA1 and c-myc in malignant and non-malignant cells still remains relatively unknown. To this adds contradicting reports regarding the oncogenic properties of EBNA1. The first EBNA1 transgenic mice model showed a lymphoma phenotype similar to that seen in eu-myc transgenic animals. Later, a second EBNA1 transgenic mouse was made but with no phenotype. There was no explanation for these discrepancies other than the first model expresses low levels of EBNA1 and the second expresses high levels. We have observed that translation disruption caused by EBNA1 triggers E2F and the induction of c-myc. This stimulates ribosomal biogenesis and it can be speculated that the virus exploits a cellular pathway that senses ribosomal stress and aims to restores ribosomal biogenesis via myc. This can help to explain the different reports on EBNA1’s oncogenic capacity and places EBV together with several other oncogenic viruses that target E2F. However, the mechanism whereby EBV activates E2F indicates a different mechanism as compared to Papilloma or Simian viruses. Amphi Pasteur CERVI |
Lundi
21 / 11 / 2016 10h00 |
"Organoïd based high content screening"
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Dr. Xavier GIDROL
IBCP Confernce Room level -1 |
Lundi
21 / 11 / 2016 11h30 |
"Structural Biology of the Pneumococcal Surface Proteins: Unraveling the Pathogenesis and Virulence Mechanisms by X-Ray Crystallography"
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Juan A. HERMOSO (Department of Crystallography and Structural Biology, Spanish National Research Council (CSIC), Madrid, Spain) Invited by C. Grangeasse Juan A. Hermoso is the leader of a research group and Full Professor of the Spanish National Research Council (CSIC) at the Institute of Physical-Chemistry “Rocasolano” in Madrid (Spain). His research focuses on multidisciplinary approach with X-ray crystallography, Protein Engineering and Bioinformatics tools aiming to provide knowledge of the three-dimensional structure of proteins and analysis of their various interactions and ligand complexes as a prerequisite for an in-depth understanding of any biological process. The research interests in his group encompass studies in the mechanisms of virulence and pathogenesis and the means of circumvent them. He focuses on the structural biology of the bacterial surface proteins involved in key functions, such as binding of the pathogen to host cellular receptors, antibiotics resistance, cell division, pathogenesis mechanisms or the remodeling of the peptidoglycan framework, which represent important mechanisms in the process of disease. IBCP Confernce Room level -1 |
Lundi
21 / 11 / 2016 14h00 |
"Evolution of Helicobacter and nickel metabolism"
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Hilde DE REUSE (Institut Pasteur, Département de Microbiologie, Unité Pathogenèse de Helicobacter, ERL CNRS 3526 PARIS - FRANCE) Contact: xavier.charpentier@inserm.fr Metal acquisition and intracellular trafficking are crucial for all cells and metal ions have been recognized as virulence Salle des Thèses Chantal Rabourdin-Combe |
Mercredi
23 / 11 / 2016 15h00 |
"A hybrid computational/experimental procedure to improve malaria vaccine design"
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Cristina FERNANDEZ ARIAS (Rockefeller University, New York - USA) Contact: christophe.arpin@inserm.fr Dr Cristina Fernandez-Arias from the Rockeffer University is a systems immunologist using formal approaches to Amphi Pasteur CERVI |
Jeudi
24 / 11 / 2016 14h30 |
"Manipulation of Host phosphoinositide metabolism by Coxiella burnetii : lessons from multiparametric high-content"
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Matteo BONAZZI (FRE3689 CNRS, Montpellier - FRANCE) Contact: thomas.henry@inserm.fr Matteo Bonazzi is heading a CNRS team termed “Cell Biology of bacterial infections” in Montpellier at the CPBS (Centre d’études d’agents pathogènes et Biotechnologies pour la santé). His team focuses on the obligate intracellular bacterium Coxiella burnetti responsible for the worldwide zoonosis Q fever. Matteo has developed multi-phenotypic screening method to study the cell biology of Coxiella infection and Coxiella virulence factors. He will tell us how Coxellia burnetti manipulates host lipid metabolism to Salle de Réunion du Sous-sol LR5 |
17-18 /11 / 2016
9h00
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International conference |
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https://lyonsysbio2015.sciencesconf.org/?lang=en Contact: François Briat francois.briat@ens-lyon.fr LyonSysBio is the yearly international conference organized by BioSyL. the Systems Biology Alliance of Lyon (http://www.biosyl.org/). |
Vendredi
25 / 11 / 2016 11h00 |
"Evolution of Primate Testis Transcriptomes”
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Mehmet SOMEL (Ankara University)
Salle des Thèses Chantal Rabourdin-Combe |