September 2017
Vendredi Salle des Thèses Chantal Rabourdin-Combe |
« Propionibacterium acnes : adhésion et inflammation » | |
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Pr. Nicolas DUPIN - Hôpital Cochin, APHP, Paris contact marc.vocanson@inserm.fr Propionibacterium acnes_ (P. acnes) est une bactérie majeure associée à la peau qui a longtemps été considérée comme une bactérie commensale, jusqu' à ce que plusieurs études révèlent qu'elle est un pathogène opportuniste impliqué dans plusieurs infections invasives. P. acnes induit une réponse inflammatoire importante via l’activation de la voie TLR2 et du recepteur CD36 associé à la NADPH oxidase (NOX1) dans les cellules de l’immunité innée et les kératinocytes conduisant à la production de cytokines et chemokines proinflammatoires et un « burst » oxidatif très important. A ce jour, le rôle de P. acnes et les mécanismes moléculaires mis en jeux lors de l’apparition de ces réactions inflammatoires restent mal connus. Notre travail s’inscrit dans la caractérisation des mécanismes moléculaires impliqués dans la relation de P. acnes avec son hôte. Plus particulièrement, nous étudions les protéines de surfaces de P. acnes qui sont impliquées dans le processus inflammatoire et dans l’interaction avec les protéines de la matrice extracellulaire de l’hôte. |
Lundi Salle de conférence IBCP |
« One ring to rule them all: From cell polarity to bacterial virulence control » | |
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Urs JENAL - Biozentrum, University of Basel, Switzerland invited by C. Grangeasse |
Vendredi Salle Condorcet* |
“Spatial self-organization of the genome in the nucleus” | |
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Irina SOLOVEI - LMU Munich Hôte : Geneviève Fourel
* Salle CONDORCET - ex Conférence 1 Place de l’Ecole – Site Monod ENS |
Lundi Salle des Thèses Chantal Rabourdin-Combe |
« Asymmetric segregation of organelles by stem cells » | |
Pekka KATAJISTO - Associate professor at Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Finland and Director of the Centre of Excellence in Stem Cell Metabolism at the Academy of Finland Hôte : Kiran Padmanabhan Stem cells can divide asymmetrically to generate one daughter cell that will differentiate, and another that retains stem cell traits. Such asymmetry opens the possibility that stem cells segregate their sub-cellular components selectively during cell division, and thereby reduce damage accumulation in the stem cell lineage. We used chronologic age of sub-cellular components, such as organelles, as a proxy for damage they may have sustained, and discovered that stem-like cells of the mammary epithelium apportion their mitochondria age-selectively and asymmetrically between daughter cells (Katajisto, Science, 2015). More specifically, old mitochondria are segregated away from the stem cell lineage into the differentiating daughter cells. I will describe our current work on how old and young mitochondria differ, and the functional relevance of age-selective organelle segregation by stem cells. |
Lundi Salle des Thèses Chantal Rabourdin-Combe |
« Mechanistic biochemistry of microtubule cytoskeleton architecture and dynamics » | |
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Thomas SURREY - The Francis Crick institut, UK Hôte : Geneviève Fourel |
Lundi Salle de conférence IBCP |
« Crystallization of an essential bacterial membrane protein involved in lipoprotein maturation » | |
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Ben WISEMAN - Stockholm university, Sweden invited by P. Falson |
Lundi Salle de conférence IBCP |
« A quantitative analysis of the HlyA Type 1 Secretion System of E. coli » | |
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Lutz SCHMITT- Institute of Biochemistry, Heinrich Heine University Düsseldorf, Germany invited by J.M. Jault Gram-negative bacteria have evolved at least six dedicated secretion systems to translocate proteins of diverse function into the extracellular media or directly into the host cell. Among these, the most “simple” system is the Type 1 secretion system (T1SS) as it is composed of only three components, an ABC transporter and a membrane fusion protein (MFP), both residing in the inner membrane, and an outer membrane protein (OMP). Common to all substrates of T1SS is a C-terminal secretion sequence that is not cleaved during or after transport. Furthermore, one prominent family of substrates contain Asp- and Gly-rich nonapeptide sequences, the so-called GG repeats. These GG repeats form the RTX (repeat in toxins) domain and are responsible for binding of Ca2+ in the extracellular space, which triggers folding of the entire substrate. |
Mardi Salle des Thèses Chantal Rabourdin-Combe |
« Suppression of adaptive immunity by Salmonella » | |
keynote seminar
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Prof. David W. HOLDEN - MRC Centre for Molecular Bacteriology and Infection, Imperial College London Contact : suzana.salcedo@ibcp.fr Salmonella enterica can cause persistent infections such as typhoid fever. Following bacterial entry into host cells, the pathogen replicates in a membrane-bound compartment called the Salmonella-containing vacuole (SCV). Bacteria respond to nutritional deprivation and the acidic pH in the vacuole lumen by activating the expression of the SPI-2 type III secretion system (T3SS). After assembly of a T3SS-linked pore in the vacuole membrane, bacteria sense the near-neutral pH of the host cell cytoplasm. This triggers the translocation of bacterial virulence proteins (effectors) into the host cell. |
Jeudi Salle des Thèses Chantal Rabourdin-Combe |
« How NanoString technology can help pushing forward your project » | |
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Jonathan LOPEZ - Plateforme BIOGENET Lyon-Sud contact: denise.aubert@ens-lyon.fr The translational research platform of Hospices Civils de Lyon, located at Lyon Sud University Hospital, offers you access to cutting-edge technologies in biopathology and molecular biology within a partnership with academics or industrials. This includes the 3D biology approach developped by NanoString that allows you to simultaneously analyse nucleic and protein targets on a single biological sample in a highly multipliable fashion. What if we could do this multi-genomic analysis directly on a tissu slide with a single-celle resolution? That is exactly what the Digital Space Profiling approach offers. |
Vendredi Amphi Pasteur - Tour Inserm CERVI * |
« The type VI secretion system : a bacterial killing machine » | |
Forum d’infectiologie
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Pr. Alain FILLOUX - Imperial College London, MRC Centre for Molecular Bacteriology and Infection, London – UK Contact : karen.moreau@univ-lyon1.fr Alain Filloux a obtenu son doctorat en 1988 à l'Université d'Aix-Marseille (France). De 1988 à 1993, il a séjourné à l'Université d'Utrecht (Pays-Bas), d'abord en tant que post-doc, puis comme professeur adjoint. En 1994, il est recruté au CNRS de Marseille (France) où il est nommé directeur d'une unité de recherche en 2003. En 2008, il est nommé professeur de microbiologie moléculaire à l'Imperial College London (Royaume-Uni) et il est directeur adjoint du Centre de biologie moléculaire et d'infection. En 2013, il est nommé rédacteur en chef pour FEMS Microbiology Reviews. Ses recherches portent principalement sur la pathogenèse bactérienne, les mécanismes moléculaires de la sécrétion de protéines, la formation de biofilms et la régulation de l'expression génique. Le modèle de système qu'il a utilisé est le pathogène bactérien Pseudomonas aeruginosa. * Merci aux visiteurs de se munir d’une pièce d’identité valide (carte d’identité ou passeport – Permis de conduire non valable) pour accéder à l’amphithéâtre Pasteur. |
Lundi Salle de conférence IBCP |
« A quantitative analysis of the HlyA Type 1 Secretion System of E. coli » | |
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Sophie HÉLAINE - Imperial College, London invited by S. Salcedo |
Vendredi Amphi Pasteur - Tour Inserm CERVI * |
« Regulation of T cell responses by distinct forms of autophagy » | |
Forum d’infectiologie
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Fernando MACIAN JUAN - Albert Einstein College of Medicine Dpt of Pathology and Institute for Aging Research Bronx – NY – USA Contact : mathias.faure@inserm.fr Fernando MACIAN JUAN has more than 20 years of experience in the study and characterization of the molecular mechanisms that regulate T cell activation and tolerance. His group has pioneered the identification and characterization of the signaling pathways, transcriptional complexes and molecular events that regulate the functional outcome following T cell receptor engagement in peripheral T cells. His studies have contributed to the identification of the transcriptional and signaling events that regulate T cell fate upon antigen encounter and determine T helper cell differentiation, activation and tolerance. In the last 10 years, his group has helped defined the roles and regulation of different forms of autophagy in T cell biology and has contributed to the establishment of autophagy as an essential cell process in the modulation of T helper cell responses. * Merci aux visiteurs de se munir d’une pièce d’identité valide (carte d’identité ou passeport – Permis de conduire non valable) pour accéder à l’amphithéâtre Pasteur. |