September 2017
Lundi 01/10/2018 Salle Condorcet |
« Regulation of epithelial homeostasis by the microbiota » | |
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Andrew NEISH (Emory University, USA) Host: François Leulier The resident prokaryotic microbiota of the intestine can influence normal gut proliferation, development, growth and response to injury. We describe a common paradigm wherein contact of prokaryotic organisms stimulate the enzymatic generation of reactive oxygen species (ROS) in the host epithelia in organisms as disparate as flies and mice. These events occur via the action of highly conserved NADPH oxidase enzymes (dNox in Drosophila and Nox1 in mammals). Interestingly, a subset of bacterial taxa, predominately Lactobacilli, potently stimulates Nox dependent ROS generation in both systems, and activates redox responsive transcriptional circuits, including the Nrf2/Keap pathway. Germ-free mice and flies exhibit reduced epithelial proliferation and increased sensitivity to tissue damage. Consistently, epithelial-specific Nox1 and Nrf2 null mice, and dNox and CnC (Nrf2 ortholog in flies) mutant Drosophila demonstrate aberrant intestinal stem cell dynamics and responses to injury. Conversely, commensal bacteria such as the Lactobacilli and Akkermansia accelerate epithelial cell movement and mucosal restitution mice and flies, and correct proliferative defects observed in germ-free animals, in a Nox1 and Nrf2 dependent fashion. At the tissue level, bacterially induced ROS generation is strikingly excluded from discrete stem cell niches, resulting in a redox gradient across stem cell compartments in both mice and flies that is absent in germ-free animals. Ectopic generation of ROS in enterocytes outside the stem cell niche phenocopied the effects of the natural microbiota. These data suggest how discrete taxa of bacterial symbionts utilize spatially compartmentalized generation of ROS for controlling highly conserved signaling events that regulate intestinal development and homeostasis
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Mardi Amphi Pasteur |
“ Dissecting mechanisms of tumor immune surveillance and immunotherapies at the single cell level ” | |
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Dr Philippe BOUSSO (Institut Pasteur à Paris) contact : melanie.wencker@inserm.fr Tumors are under the selective pressure of the immune system. While the concept of tumor immunosurveillance is well-established, a number of key questions remains. At what stages of the tumor development does the immune system have the ability to eliminate malignant cells? How and where do cytotoxic effectors such as NK cells or CD8+ T cells restrict tumor progression? How do interactions between immune cells and tumor cells change as the disease progresses? Moreover, the rationale design and optimization of tumor immunotherapies critically require a better understanding of their mechanism of action in vivo. In this presentation, we will discuss how intravital imaging can help gain new insight into mechanisms at play during tumor immunosurveillance and uncover the mode of action of tumor immunotherapies |
Lundi Amphi Pasteur |
“ In the Lego box of the TCR system : from the list of parts to the assembly instructions ” | |
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Dr Bernard MALISSEN (Centre d’Immunologie Marseille-Luminy – France) contact : thierry.walzer@inserm.fr
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Jeudi 11/10/2018 Journées Scientifiques SFERETE-TEU-SFVB 2018 |
"Journées Scientifiques SFERETE-TEU-SFVB 2018" | |
Thèmes : Organisation conjointe: |
Vendredi 12/10/2018 Grande salle de réunion M6 ENS |
« Modelling early mammalian development » | |
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Geneviève DUPONT (Unité de Chronobiologie Théorique, Université Libre de Bruxelles) Contact : Olivier Gandrillon
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Lundi Salle de conférence IBCP |
“ Cryo-EM structures of retroviral intasomes ” | |
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Allison BALLANDRAS-COLAS (The Francis Crick Institute, London, UK) Invited by P. Gouet |
Lundi Grande salle de réunion M6 ENS |
« Metabo-Devo »: Drosophila HNF4 directs a switch in lipid metabolism that supports the transition to adulthood » | |
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Gilles STORELLI (Utah University) Contact : B. Mollereau |
Vendredi Salle des Thèses Chantal Rabourdin-Combe |
« Le génome humain:une vue d’ensemble sur son organisation et son évolution » | |
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Giorgio BERNARDI (Università Roma Tre, Italia) Le point de départ du séminaire portera sur la vision que nous avions du génome en 1959, ainsi que les changements qui |
Vendredi 26/10/2018 11H Salle des Thèses Chantal Rabourdin-Combe |
« Metabolism of DNA joint molecules during homologous recombination: break-up and ménage-à-trois on the path to fidelity » | |
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Aurèle PIAZZA (Institut Pasteur Paris |