Lundi 01/10/2018
11h

Salle Condorcet

Andrew NEISH (Emory University, USA)

Host: François Leulier

The resident prokaryotic microbiota of the intestine can influence normal gut proliferation, development, growth and response to injury. We describe a common paradigm wherein contact of prokaryotic organisms stimulate the enzymatic generation of reactive oxygen species (ROS) in the host epithelia in organisms as disparate as flies and mice. These events occur via the action of highly conserved NADPH oxidase enzymes (dNox in Drosophila and Nox1 in mammals). Interestingly, a subset of bacterial taxa, predominately Lactobacilli, potently stimulates Nox dependent ROS generation in both systems, and activates redox responsive transcriptional circuits, including the Nrf2/Keap pathway. Germ-free mice and flies exhibit reduced epithelial proliferation and increased sensitivity to tissue damage. Consistently, epithelial-specific Nox1 and Nrf2 null mice, and dNox and CnC (Nrf2 ortholog in flies) mutant Drosophila demonstrate aberrant intestinal stem cell dynamics and responses to injury. Conversely, commensal bacteria such as the Lactobacilli and Akkermansia accelerate epithelial cell movement and mucosal restitution mice and flies, and correct proliferative defects observed in germ-free animals, in a Nox1 and Nrf2 dependent fashion. At the tissue level, bacterially induced ROS generation is strikingly excluded from discrete stem cell niches, resulting in a redox gradient across stem cell compartments in both mice and flies that is absent in germ-free animals. Ectopic generation of ROS in enterocytes outside the stem cell niche phenocopied the effects of the natural microbiota. These data suggest how discrete taxa of bacterial symbionts utilize spatially compartmentalized generation of ROS for controlling highly conserved signaling events that regulate intestinal development and homeostasis

Mardi
02/10/2018
11h

Amphi Pasteur

Dr Philippe BOUSSO (Institut Pasteur à Paris)

contact : melanie.wencker@inserm.fr

Tumors are under the selective pressure of the immune system. While the concept of tumor immunosurveillance is well-established, a number of key questions remains. At what stages of the tumor development does the immune system have the ability to eliminate malignant cells? How and where do cytotoxic effectors such as NK cells or CD8+ T cells restrict tumor progression? How do interactions between immune cells and tumor cells change as the disease progresses? Moreover, the rationale design and optimization of tumor immunotherapies critically require a better understanding of their mechanism of action in vivo. In this presentation, we will discuss how intravital imaging can help gain new insight into mechanisms at play during tumor immunosurveillance and uncover the mode of action of tumor immunotherapies

Lundi
08/10/2018
11h

Amphi Pasteur

Dr Bernard MALISSEN (Centre d’Immunologie Marseille-Luminy – France)

contact : thierry.walzer@inserm.fr

Jeudi 11/10/2018
et Vendredi 12/10/2018
11h

Journées Scientifiques SFERETE-TEU-SFVB 2018

Thèmes :
– Cancer, Eléments inorganiques et Vitamines
– Communications orales sur toute thématique en lien avec les éléments inorganiques ou les vitamines

Organisation conjointe:
-Société Francophone d’Etude et de Recherche des Eléments Toxiques et Essentiels
-Trace Element, institut pour l’Unesco (TEU)
-Société Francophone des Vitamines et Biofacteurs (SFVB) http://www.sferete.fr/

Vendredi

12/10/2018
11h

Grande salle de réunion M6 ENS

Geneviève DUPONT (Unité de Chronobiologie Théorique, Université Libre de Bruxelles)                    

Contact : Olivier Gandrillon

Lundi
15/10/2018
11h

Salle de conférence IBCP

Allison BALLANDRAS-COLAS (The Francis Crick Institute, London, UK)                     

Invited by P. Gouet

Lundi
15/10/2018
11h

Grande salle de réunion M6 ENS

Gilles STORELLI (Utah University)         

Contact : B. Mollereau

Vendredi
19/10/2018
11h

Salle des Thèses Chantal Rabourdin-Combe

Giorgio BERNARDI (Università Roma Tre, Italia)    

Le point de départ du séminaire portera sur la vision que nous avions du génome en 1959, ainsi que les changements qui
ont eu lieu dans les années ‘60 et ‘70, en particulier la découverte des isochores. Un rappel de nos connaissances sur le lien
entre les isochores riches ou pauvres en GC et les structures ouverte ou fermée de la chromatine dans le noyau interphasique
ainsi que sur les « chromatin domains » (les « Lamina Associated Domains », ou LADs, et les « Topologically Associating
Domains », ou TADs) permettra de passer aux résultats récents:
1) la coincidence des cartes chromosomiques des isochores pauvres et riches en GC avec les cartes des LADs et des TADs
2) les modèles de formation des « chromatin domains »;
3) la structure tridimensionnelle de l’ADN ;
4) le rôle joué par les courtes séquences (di- et tri-nucléotides) dans la structure 3-D de l’ADN ;
5) le rôle de l’ADN non-codifiant pour les protéines. Finalement, on prendra en considération la manière dont le génome
évolue.

Vendredi 26/10/2018

11H

Salle des Thèses Chantal Rabourdin-Combe