September 2017
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Lundi 09/09/2019 Salle Condorcet Séminaire externe |
« Sex determination and sex chromosome evolution in fish » | |
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Manfred SCHARTL ( Universityof Würzburg) Host: Abderrahman Khila
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Mardi 10/09/2019 Salle des Thèses CRC Séminaire Externe |
“ Stromal immune regulation in pancreas ” | |
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Dr. Anca HENNINO (CRCL) contact : henri.gruffat@ens-lyon.fr
Pancreas is a complex organ that ensures endocrine and exocrine functions. It is a soft tissue in normal healthy conditions but can become a stiff tissue upon inflammation and/or transformation. This phenomenon is largely due to the accumulation of an abundant stromal reaction within the tissue. Since few years the contribution of this massive stroma has emerged as a novel actor and contributor of pancreatic tumour initiation and progression. We identified βig-h3 stromal-derived protein as a key actor of the immune paracrine interaction mechanism that drives pancreatic cancer. We found that βig-h3 is highly produced by cancer-associated fibroblasts in the human and mouse stroma. This protein acts directly on tumour-specific CD8+ T cells and F4/80+ macrophages. Depleting βig-h3 in vivo reduced tumour growth by enhancing the number of activated CD8+ T cell within the tumour and subsequent apoptotic tumour cells. Furthermore, we found that targeting βig-h3 in established lesions released the tissue tension and functionally reprogrammed F4/80 macrophages in the tumour microenvironment. Our findings present βig-h3 as a novel immunological target in pancreatic cancer. |
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Jeudi 12/09/2019 Salle des Thèses CRC Séminaire Externe |
“ Protein coevolution and the viral world ” | |
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Dr Alessandra CARBONE (Dpt of Computational and Quantitative Biology, Sorbonne Universty & CNRS - Paris) Contact : jimena.perez-vargas@inserm.fr A fundamental question in computational biology is the extraction of evolutionary information from protein sequences. This information relates to protein-protein binding sites and the mechanical and allosteric properties of proteins. We will present a computational approach for co-evolution analysis and apply it to the reconstruction of viral genome protein networks. We will show how the interaction network of the hepatitis C virus genome proteins can be reconstructed at a residue / domain resolution and will briefly present recent experimental work demonstrating the fusion of HCV as a unique mechanism. This work provides a proof of concept for a broader exploration of viral protein-mediated processes and highlights coevolution as a valuable tool for guiding the design of viral inhibitors. In a second example, we will show how, a generalization of the method applied to the hepatitis B virus, provides important information on primary and secondary mutations in response to antiviral drugs. |
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Lundi 16/09/2019 11H00 Salle IBCP Conf Séminaire Externe |
“ Molecular investigation of host-pathogen interactions in enterohemorrhagic E. coli infections ” | |
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Grégory JUBELIN (INRA Clermont Ferrand) Invited by S. Bigot
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Lundi 16/09/2019 11H00 Salle Condorcet Séminaire externe |
« Life after Meiosis : Evolution and Control of Plant Male Germline Development » | |
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David TWELL (University of Leicester, UK) Host: Thomas Widiez |
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Mardi 18/09/2019 11h Amphi Pasteur Forum infectiologie "spécialité Bactériologie" |
“ Comparative transcriptomics identifies a single SNP mutation that controls virulence of African Salmonella ” | |
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Pr. Jay HINTON (Institute of Integrative Biology University of Liverpool)
Contact : xavier.charpentier@univ-lyon1.fr
With 3.4 million infections each year, invasive non-Typhoidal Salmonella (iNTS) is a major cause of illness worldwide. In Sub-Saharan Africa bloodstream infections with iNTS Salmonella enterica serovar Typhimurium are causing ~388,000 deaths annually. Co infection with HIV or malaria in adults, and a young age (<5 years) are known risk factors. Using a combination of comparative genomics and comparative transcriptomics, we discovered phenotypic differences that distinguish African from global Salmonella pathovariants (Canals et al., 2019). Our analysis led us to identify a single core genome SNP responsible for the up-regulation of a single promoter in strain D23580 that controlled the expression of a Salmonella virulence factor (Hammarlöf et al., 2018), and offers part of the explanation of the pan-African epidemic of bloodstream infection.
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Vendredi 20/09/2019 11h Salle des Thèses CRC Séminaire externe |
« The Dynamic Nucleus during Embryogenesis » | |
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Dr. Susan MANGO (Biozentrum, University of Basel) Contact : Equipe Palladino The nucleus undergoes dramatic reorganization during embryogenesis, from transcriptional quiescence at fertilization to pluripotency and ultimately to a heterogeneous, differentiated state with distinct patterns of gene expression and chromatin organization. I will discuss our newly developed method of multiplex chromosome tracing and our studies of DNA organization during embryogenesis. I will highlight the factors and processes that dictate the formation of silent heterochromatin. |
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Mardi 24/09/2019 11H00 Salle Condorcet Séminaire externe
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« Dental cell type atlas reveals new stem and differentiated cell types in mouse and human teeth » | |
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Dr. Jan KRIVANEK (Masaryk University, Tchéquie) Contact : Sémon Pantalacci
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Lundi 30/09/2019 11h Salle IBCP Conf Séminaire externe |
“titre à venir ” | |
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Jean CELLI (Paul G. Allen School for Global Animal Health, Washington State University, USA) Invited by S. Salcedo |
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