Dear Scientist,

We are pleased to announce the new PHENOMIN call dedicated to generation and characterization of CreER^T2 cell specific promoter driven deleter mouse lines.

Since 2011, PHENOMIN has generated more than 150 models with conditional potential. In the frame of the International Mouse Phenotyping Consortium (IMPC) more than 5,000 genes are already committed to the IMPC pipeline. Most of these models can be driven in conditional alleles.  

We aim to maximize the utility of this resource by offering the scientific community with the possibility to nominate the making of new Cre or CreER^T2 lines.

In the last decade, we have generated and validated more than 30 cell specific inducible CreER^T2 deleter lines (Mouse Cre and CreER^T2 zoo).  We have written guidelines for using cre/lox system in mice (European FP7 CREATE program, Cre related resources and databases). We developed a highly efficient universal cre deleter line (Genesis. 2012 Jun;50(6):482-9). As a partner in EUCOMTOOLS effort, we are establishing new 250 CreER^T2 knock-in models (EUCOMMTools Program) in a pure C57BL/6N background.

The call targets the French scientific community. It is a real opportunity to nominate the making of new CreERT2 drivers with useful expression patterns. Projects will be selected on scientific bases and non-availability of similar Cre/CreER^T2 lines available in other repositories. Proposals will be reviewed by a scientific committee.

To apply to this call, please fill in the application form.

Application deadline is 15^th of October 2015