Avril 2022
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Lundi 04/04/2022 IBCP Salle conf Séminaire Externe |
« Molecular basis for the transfer of large toxin plasmids in Clostridium perfringens » | |
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Daouda A.K. TRAORE (Life Science Group, Institut Laue Langevin, Grenoble)
Host : P. Gouet ; C. Grangeasse
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Lundi 04/04/2022 SDT CRC Séminaire Externe
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"Genomics of phenotypic plasticity" | |
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Arild HUSBY (Department of Evolution and Genetics, Uppsala University, Sweeden)
Hôte : Abberraman Khila
Phenotypic plasticity is an important mechanism allowing organisms to adapt to changing environmental conditions yet we know little about its genetic basis. Over the last few years there have been significant progress in understanding how plastic traits are regulated at the genomic level and in this talk I will discuss this recent progress with a specific focus on seasonal timing of reproduction in birds and wing polyphenism in insects - both classic phenotypically plastic traits closely associated with individual fitness. By the use of genome wide association studies and epigenetic work on different natural populations of birds we have found that, by and large, all traits support the assumptions from classic quantitative genetic work of a polygenic basis with the involvement of both genetic and epigenetic effects. Studying plasticity in the wild is however challenging, the lack of control over the environmental conditions and limited possibility to sample relevant tissue for studying RNA expression and DNA methylation limits our possibilities for deep insights into genetics of plasticity. In contrast, studying the genetic basis of plasticity in wing development in insects circumvents these issues and also allow for functional work to deepen our understanding of how environmental cues impact wing size variation within and between species and I will present some recent work where we examine the genetic basis of wing polyphenism in water striders.
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Jeudi 07/04/2022 SDT CRC Séminaire Externe |
"Non-invasive isotope-based hydrodynamic imaginig in plant roots at cellular resolution" | |
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Valentin COUVREUR (Université Catholique de Louvain)
Host: Jeanne-Abitbol-Spangaro
ANNULE - CANCELED |
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Mardi 12/04/2022 Amphi G4 ISFA 50 avenue T.GARNIER Mini symposium |
Mini-Symposium - Host L. Lecoq | |
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Hartmut OSCHKINAT (FMP, Berlin) : « Unexpected refolding events in B. subtilis biofilm formation studied by an interplay of NMR and AlphaFold »
Carine van HEIJENOORT (ICSN, Gif-sur-Yvette) : « TBA »
Malene R JENSEN (IBS Grenoble) « Combining NMR spectroscopy and X-ray crystallography to visualize protein breathing motions »
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Vendredi 15/04/2022 Salle SDT CRC Séminaire Externe |
« Gene regulatory network reconstruction and simulation in presence of transcriptional bursting » | |
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Ulysse HERBACH (INRIA Nancy)
Contact Olivier Gandrillon
Inferring regulatory networks from gene expression data is a longstanding question in systems biology. So far, most studies have been based on the bulk data paradigm: now that technologies enable to observe mRNA levels in individual cells, a revolution in terms of precision, the network reconstruction problem paradoxically remains more challenging than ever. Indeed, the traditional way of seeing a gene regulatory network as a deterministic system with some small external noise is being challenged by the probabilistic, bursty nature of gene expression revealed at single-cell level.
Here we describe a strategy in which network inference is seen as a calibration procedure for a mechanistic model driven by transcriptional bursting: this model inherently captures the typical variability of single-cell data without requiring ad hoc external noise. This approach has three interesting features: it is computationally tractable with realistic numbers of cells and genes, it provides inferred networks with biological interpretability, and the underlying mechanistic model allows testable predictions to be made. This work is in collaboration with Elias Ventre, Thibault Espinasse, Gérard Benoit and Olivier Gandrillon. |
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