Fevrier 2021
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Lundi 01/02/2021 Visio Séminaire Externe |
« Rational design of peptide inhibitors for the Type 6 Secretion System assembly » | |
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Riccardo PELLERIN (Pasteur Institute,Paris)
Host: L. Monticelli
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Lundi 01/02/2021 Visio Séminaire Externe
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« Fate and functions of plasmacytoid dendritic cells » | |
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Dr. Elena TOMASELLO (CIML, Marseille – France)
Hôte: marlene.dreux@ens-lyon.fr
Plasmacytoid dendritic cells (pDCs) are the major source of type I and type III interferon (IFN) during most systemic viral infections. pDCs are thus considered crucial for anti-viral immunity. What other functions pDCs exert in vivo during viral infections is controversial. In particular, pDC ability to act as antigen presenting cells, like conventional DC (cDC), was recently attributed to a potential contamination by other cells, such as pDC-like or transitional DC (tDC), harbouring a mixed cDC/pDC phenotype. By combining Ifnb1 reporter mice with flow cytometry, single-cell RNA sequencing, confocal microscopy and a cognate CD4 T cell activation assay, we characterized in depth and linked pDC activation states in animals infected by mouse cytomegalovirus. We showed that IFN-I production and T cell activation were performed by the same pDC, but these functions occurred sequentially in time and in different micro-anatomical locations. Individual pDCs are thus endowed to exert different functions in vivo during a viral infection, in a manner tightly orchestrated in time and space. We have recently developed novel mouse models allowing to specifically track or deplete pDC. Thanks to these unique tools we will discriminate “bona fide” pDC from pDC-like or tDC and evaluate their respective functions. |
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Lundi 01/02/2021 Visio Séminaire Externe |
« Stem cell promoting activity of CLAVATA peptide signaling in Marchantia polymorpha » | |
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Yuki Hirakawa (Gakushuin University, Japan)
Host: Olivier Hamant
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Lundi 15/02/2021 Visio Séminaire Externe |
« Phase transitions in morphogenesis » | |
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Edouard Hannezo (IST Vienna, Austria)
Host: Yoan Coudert
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Lundi 15/02/2021
16H00
Visio Séminaire externe |
« Flexible plumbing : vascular developmental plasticity in response to environmental cues » | |
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Antia Rodriguez (ETH Zurich, Switzerland)
Host: Yvon Jaillais
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Lundi 22/02/2021 11H00 Visio Séminaire externe |
« Fences in turmoil : interplay between plant cell walls and jasmonate production » | |
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Debora Gasperini (Leibniz Institute of Plant Biochemistry, Germany)
Host: Olivier Hamant
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Lundi 22/02/2021 16h Visio Séminaire externe |
« Morphogenetic movements in plants » | |
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Julien Derr (Université Paris Diderot, France)
Host: Gwyneth Ingram
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