Novembre 2025
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Lundi 03/11/2025 11h00
Salle des thèses CRC Séminaire externe |
“ Examining Dynamic Behaviours during Zebrafish Heart Regeneration ” |
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Phong NGUYEN (Institut Curie)
Hôte : F. MARMIGERE
The adult zebrafish heart can robustly regenerate its heart following an injury unlike mammalians. Uncovering the mechanisms by which this occurs is however limited to histological and next generation sequencing methods due to the inaccessibility of the heart at adult stages. We predict that heart regeneration is highly dynamic and consequently developed an ex vivo imaging set up that allows the long term culture of cardiac slices that is also compatible to live timelapse imaging. In this seminar, I will present our latest findings on the dynamics observed in various cell types that are actively partipicating in regeneration.
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Mardi 04/11/2025 11h00
Salle de séminaire
IBCP
Séminaire externe
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Présentation du Centre de Ressources Biologiques des HCL | |
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Anthony TERRA & Charlotte LACROIX (Centre de ressources biologiques des HCL)
Hôte : B. FROMY
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Jeudi 06/11/2025 14h00
Salle des thèses CRC
Séminaire externe
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“ Somatic mutations HTLV-1 carriers - early predictors of malignant transformation ” | |
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Aileen ROWAN (Imperial College London) Hôte : J. TURPIN & C. JOURNO |
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Vendredi 07/11/2025 Journée
Amphi Charles Mérieux
Symposium
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“ 8th symposium of the French Network on Monocytes-Macrophages (SoMM2025) ” | |
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https://somm2025.sciencesconf.org/
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Lundi 10/11/2025 11h00
Salle des thèses CRC
Séminaire externe
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“ TBC ” | |
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Sarah ROBINSON (The Sainsbury Laboratory, University of Cambridge, UK) Hôte : C. KIRCHHELLE
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Mercredi 12/11/2025 14h00
Amphi L (ENS)
Séminaire externe
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“ Vers une résonance magnétique 10'000 fois plus sensible au service de la biologie ” | |
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Sami JANNIN (Enseignant-Chercheur à l'ISA) Hôte : S. TROUILLET-ASSANT |
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“ Spatial transcriptomics (2D) on a nice annelid model for regeneration, Platynereis dumerilii ” | ||
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Eve GAZAVE (Institut Jacques Monod, Paris) Hôte : Z. CHAKER |
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Lundi 17/11/2025 11h00
Salle de réunion M6
Séminaire externe |
" TBC " | |
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Takashi UEDA (National Institute for Basic Biology, Japan) Hôte : Y. HASEGAWA
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Lundi 17/11/2025 14h00
Salle Condorcet
Séminaire externe |
" The IRF1-driven constitutive immunity - a hallmark of mature hepatocytes - restricts Hepatitis D virus infection " | |
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Franke LANGE (Twincore, Hannovre, Allemagne) Hôte : E. VERRIER
Frauke Lange first studied biology at the Gottfried Wilhelm Leibniz Universität Hannover and then transferred to the Hannover Medical School for her master's degree in Biomedicine. She conducted her master's thesis in the institute for experimental virology in the lab of Thomas Pietschmann at TWINCORE under supervision of Arnaud Carpentier, where she described stem-cell derived hepatocytes (HLCs) as a mature cell model for Hepatitis D virus infection. Frauke stayed at the institute for her PhD thesis, where her research focused on the control of Hepatitis D virus infection in the same cell model. Using single cell RNA sequencing of infected HLCs, she and Arnaud Carpentier identified IRF1, a constitutively active transcription factor and regulator of antiviral gene expression, as a restriction factor of HDV infection, specifically targeting the cell division-mediated spread of HDV. |
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Mardi 18/11/2025 11h00
Amphi Pasteur
Séminaire externe |
" TBC " | |
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Guido PAPA Hôte : P-O. VIDALAIN |
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Lundi 24/11/2025 11h00
Séminaire externe |
" TBC " | |
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Audrey DUSSUTOUR (Research Center on Animal Cognition (CRCA), CBI Toulouse) Hôte : C. GODIN
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Vendredi 28/11/2025 11h00
Salle des Thèses CRC
Séminaire externe |
" Programmed DNA double-standed breaks during meiosis: Mechanisms & evolution " | |
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Bernard DE MASSY (Institut de Génétique Humaine (IGH), Montpellier) Hôte : A. PIAZZA
Meiotic cells have developed a sophisticated molecular pathway allowing homologous chromosome to pair, be connected and exchanged. This pathway relies on homologous recombination events which are initiated by the programmed induction of DNA double strands breaks (DSBs). The absence of meiotic recombination leads to sterility. In mammals, about 300 DSBs are induced in each oocyte or spermatocyte at the onset of the first meiotic prophase.
We discovered several years ago that the distribution of meiotic recombination is determined by PRDM9 in humans and mice. PRDM9 is a sequence-specific DNA binding protein with a methyl-transferase activity, catalysing H3K4me3 and H3K36me3. We also identified the long-sought missing subunit for DNA break formation, TOPOVIBL, a partner of SPO11 carrying the catalytic activity, and also highlighting the evolutionary link with Type II DNA Topoisomerases. I will present our current view of how PRDM9 mediates its function at the DNA level and in the context of chromosome organisation, and report recent insights into its evolutionary conservation.
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