September 2017
Lundi 03/10/2022 Salle SDT CRC Séminaire Externe |
« Systematic optimization and development of plant genome editing » | |
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Thomas JACOBS
Host : Yoan Coudert
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Mercredi 05/10/2022 Salle SDT CRC Séminaire Externe |
« MACSima Imaging System » | |
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Camille Godon
(Imaging Sales Specialist ; Miltenyi Biotec’s MACSima Imaging Platform)
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Vendredi 07/10/2022 Salle SDT CRC Séminaire Externe |
« Specificity and function of Argonaute protein-mediated pathways » | |
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Karina JOURAVLEVA (Université du Massachussetts Medical School)
Hôte : Equipe Ricci
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Vendredi 14/10/2022 11H00 Salle SDT CRC Séminaire Externe |
« Different contributions of epithelium and mesenchyme in patterning of the skin » | |
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Denis HEADON (University of Edinburgh, UK)
Hôte : Equipe Pantalacci Sémon
Denis has published extremely rigorous and clever papers combining experimental cell biology and mathematical modeling to study the formation of reapeted patterns, such as feathers and hair pattern. His work shows how these Turing-like mechanisms rely on both diffusing signaling molecules and cell behaviors as migration or compaction.
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Lundi 17/10/2022 11H00 Salle SDT CRC Séminaire externe |
« Mechanism of homologous recombination: The roles of the Rad54 and Rdh54/Tid1 motor proteins » | |
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Wolf-Dietrich HEYER (UC Davis)
Hôte : Equipe Piazza
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Lundi 17/10/2022 15h Webinar |
« Time matters in biology » | |
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Ludovic ORLANDO & Ana FISZBEIN
1. Ludovic Orlando, CNRS Research Director at the Center for Anthropobiology and Genomics of Toulouse. Ludovic’s pioneering work helped understand the origin of horse domestication using ancient DNA. To learn more about Ludovic’s research, click here. Ludovic’s presentation will be entitled “The genomics history of horses and donkeys”.
2. Ana Fiszbein, Assistant Professor at Boston University. Ana’s work focuses on co-transcriptional gene regulation of mammalian expression programs. To learn more about Ana’s research, click here. Her presentation will be entitled “The mysteries of co-transcriptional gene regulation”. IGFL webinar series Link for the meeting: https://cnrs.zoom.us/j/98625501525?pwd=enhNWTdEYnphRFJKTkhBeVpLZW5MQT09
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Mardi 18/10/2022 11h Salle Condorcet Séminaire externe |
« Deep mutational scanning of entire human protein interaction domain families » | |
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Guillaume DISS (Friedrich Miescher Institute (FMI) - Basel, Switzerland)
Hôte : Equipe Francesconi
To address the sequence-function relationship in protein-protein interactions, we conducted a deep mutational scanning of the entire human basic leucine zipper (bZIP) interaction network. Using our established double-deepPCA system, we measured the effect of all single amino acid substitutions in all 54 members, on the affinity for all 54 wild-type members. This dataset of ~2M quantitative protein-protein interaction measurements enabled training a deep neural network that captures the sequence-function relationship in order to quantitatively predict the free energy of binding between two bZIPs from their sequence alone. I will present the dataset and the deep learning model, as well as preliminary data on two other families, basic helix-loop-helix and SH3 domains, for which we plan to collect 6 and 20M affinity measurements respectively. We foresee that applying this strategy on a variety of domain families of different architecture will enable the development of general models that can predict the affinity of an interaction from the sequence of the two partners. |
Vendredi 21/10/2022 11h Séminaire externe |
« Nuclear magnetic resonance for plants : fascination of imaging » | |
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Ljudmilla Borisjuk
Host : Gwyneth Ingram
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