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AniRA Mouse models

https://www.sfr-biosciences.fr/projets-labellises/Anira/mousemodels/leadImage

Purpose

The Experimental mouse models core facility generates and produces genetically modified mice as well as infectious models analysis. This core facility provides a wide variety of services and constantly develops new tools to generate and validate experimental models.

The AniRA-Experimental mouse models facility has an animal core facility (Anira-PBES) that includes a state-of-the-art unit for transgenesis by lentiviral vectors, among others, developed with the genetic analysis core facility (AniRA-Genetic Analysis) and the vectorology core facility (Anira-Vectorology). The Anira-PBES animal facility has protected areas for experiments that require A1, A2 and A3 containment for proper handling of infectious models. The facility also has a L3 laboratory (AniRA-BSL3) that provides the scientific community with infectious animal models.

 

SERVICES

 

PRODUCTION OF VIRAL VECTORS

GENERATION OF MUTANT LINES

DECONTAMINATION OF LINES AND CRYOPRESERVATION

GENOTYPING

BREEDING AND PRODUCTION OF MURINE LINES

MOUSE INFECTIOUS MODELS

 

QUALITY MANAGEMENT

To respond more effectively to the needs of their users and also, to ensure transparency and reliability of research results, the Management of the SFR BioSciences is committed to implement an ISO 9001 quality policy. To this end, it has created a Quality Management Department. This department actively coordinates the implementation of the quality projects of the technical core facilities of the SFR, especially those of the regional AniRA facility certified with the IBiSA label.

More information on Quality managment

 

ANIRA R&D PROGRAM

Since 2014, SFR Biosciences organizes a yearly call for proposals to support innovative and collaborative projects of methodological or technological development. Projects are evaluated by a scientific committee that consists of four researchers and four staff members of the core facilities. Projects are evaluated based on their scientific quality, innovative nature, value for the scientific community, and potential new services for the SFR Biosciences.

AniRA R&D project supported in 2017

  • Insertion ciblée de gros fragments (Editing souris)

 

AniRA R&D projects supported in 2016

  • Recombinaison homologue par CRISPR/Cas9 chez la souris
  • Livraison non intrusive de matériel génétique dans l’ovocyte de souris

 

AniRA R&D projects supported in 2015

  • Zisupton : création d'un nouveau vecteur à l'aide d'un transposon

 

AniRA R&D projects supported in 2014

  • Création de séries alléliques par CRISPR/Cas9 chez la souris